| ACApac Carolina Crusher 2 | Florence, SC | Machinery Manufacturing333120 | — | ◇ UNVERIFIED |
| CSConcrete Supply CO LLC - Envision Temp Plant | Florence, SC | Nonmetallic Mineral Product Manufacturing327320 | — | ◇ UNVERIFIED |
| CSConcrete Supply CO LLC Johnsonville Spare | Florence, SC | Nonmetallic Mineral Product Manufacturing327320 | — | ◇ UNVERIFIED |
| CSConcrete Supply CO LLC - Timmonsville | Timmonsville, SC | Nonmetallic Mineral Product Manufacturing327320 | — | ◇ UNVERIFIED |
| CLCrenlo LLC | Florence, SC | Fabricated Metal Product Manufacturing332117 | — | ◇ UNVERIFIED |
| CRC R Jackson INC - Pugmill | Florence, SC | Nonmetallic Mineral Product Manufacturing327320 | — | ◇ UNVERIFIED |
| DSDarlington Shredding INC | Darlington, SC | Primary Metal Manufacturing331492 | — | ◇ UNVERIFIED |
| DCDawkins Concrete Products INC | Hartsville, SC | Nonmetallic Mineral Product Manufacturing327320 | — | ◇ UNVERIFIED |
| DMDelta Mills Pamplico Cypress | Pamplico, SC | Textile Mills313210 | — | ◇ UNVERIFIED |
| DTDupont Teijin Films | Florence, SC | Chemical Manufacturing325211 | — | ◇ UNVERIFIED |
| EWEsab Welding and Cutting Products | Florence, SC | Machinery Manufacturing333992 | — | ◇ UNVERIFIED |
| GLGaley & Lord Society Hill | Society Hill, SC | Textile Mills313310 | — | ◇ UNVERIFIED |
| HOHartsville Oil Mill | Darlington, SC | Food Manufacturing311223 | — | ◇ UNVERIFIED |
| IBInterstate Brands CORP - Closed | Florence, SC | Food Manufacturing311812 | — | ◇ UNVERIFIED |
| JRJames River Paper Company Incorporated | Darlington, SC | Paper Manufacturing322215 | — | ◇ UNVERIFIED |
| MFMaytag Florence Operations | Florence, SC | Machinery Manufacturing333921 | — | ◇ UNVERIFIED |
| NMNew Millennium Building System S INC | Florence, SC | Fabricated Metal Product Manufacturing332312 | — | ◇ UNVERIFIED |
| NCNucor Cold Finishing | Darlington, SC | Primary Metal Manufacturing331110 | — | ◇ UNVERIFIED |
| OEOtis Elevator Company Solar | Florence, SC | Machinery Manufacturing333921 | — | ◇ UNVERIFIED |
| PDPee Dee Ready Mix | Effingham, SC | Nonmetallic Mineral Product Manufacturing327320 | — | ◇ UNVERIFIED |
| POPepsi-cola of Florence LLC | Florence, SC | Beverage and Tobacco Product Manufacturing312111 | — | ◇ UNVERIFIED |
| P8Plant 84 - Florence | Florence, SC | Nonmetallic Mineral Product Manufacturing327320 | — | ◇ UNVERIFIED |
| RMReady Mixed Concrete #84 Florence-closed | Florence, SC | Nonmetallic Mineral Product Manufacturing327320 | — | ◇ UNVERIFIED |
| RBRoller Bearing CO of America | Hartsville, SC | Fabricated Metal Product Manufacturing332721 | — | ◇ UNVERIFIED |
| RFRuiz Foods - Florence Facility | Florence, SC | Food Manufacturing311412 | — | ◇ UNVERIFIED |
| SPSc Prestress Lakecity | Lake City, SC | Nonmetallic Mineral Product Manufacturing327320 | — | ◇ UNVERIFIED |
| SCSouth Carolina Prestress CORP | Florence, SC | Nonmetallic Mineral Product Manufacturing327320 | — | ◇ UNVERIFIED |
| TSTechno Steel LLC | Darlington, SC | Fabricated Metal Product Manufacturing332323 | — | ◇ UNVERIFIED |
| TPToppan Packaging USA INC. | Hartsville, SC | Paper Manufacturing322220 | — | ◇ UNVERIFIED |
| WPWellman Plastics Recycling LLC | Johnsonville, SC | Textile Product Mills314999 | — | ◇ UNVERIFIED |
| 3F370 - Florence | Florence, SC | Nonmetallic Mineral Product Manufacturing327320 | 20–99 | ◐ LIKELY ACTIVE |
| AIABB Inc Florence | Florence, SC | Electrical Equipment, Appliance & Component Manufacturing335313 | 100–499 | ◐ LIKELY ACTIVE |
| BRBlack River Distillery, INC. | Pamplico, SC | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| BDBoxwood Distillery, LLC | Florence, SC | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| CFCarolina Fresh Foods | Florence, SC | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| CCCarter Component Plant 546 | Johnsonville, SC | Wood Product Manufacturing321214 | 20–99 | ◐ LIKELY ACTIVE |
| CMCrescent Moon Vineyard, INC. | Timmonsville, SC | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| CCCrown Cork & Seal USA, Inc. - Effingham Plant | Effingham, SC | Fabricated Metal Product Manufacturing332431 | 20–99 | ◐ LIKELY ACTIVE |
| CCC&S Chemicals - Darlington, SC | Darlington, SC | Chemical Manufacturing325180 | 20–99 | ◐ LIKELY ACTIVE |
| DDarlington | Darlington, SC | Chemical Manufacturing325211 | 100–499 | ◐ LIKELY ACTIVE |
| DQDenise Quarles | Florence, SC | Chemical Manufacturing325620 | — | ◐ LIKELY ACTIVE |
| ECEast Coast Tvm LLC | Timmonsville, SC | Fabricated Metal Product Manufacturing332999 | — | ◐ LIKELY ACTIVE |
| FIFlorence ICG Plant | Florence, SC | Wood Product Manufacturing321215 | 100–499 | ◐ LIKELY ACTIVE |
| GFGEHC Florence SC HCS | Florence, SC | Computer and Electronic Product Manufacturing334510 | 500+ | ◐ LIKELY ACTIVE |
| JSJohnsonville Sc Door Millwork Hub 486 | Johnsonville, SC | Wood Product Manufacturing321911 | 20–99 | ◐ LIKELY ACTIVE |
| KFKoppers Florence | Florence, SC | Wood Product Manufacturing321114 | 20–99 | ◐ LIKELY ACTIVE |
| KTKquadrick Tyreik-rudell Harrison | Florence, SC | Miscellaneous Manufacturing339113 | — | ◐ LIKELY ACTIVE |
| NBNiagara Bottling, LLC - Florence | Florence, SC | Beverage and Tobacco Product Manufacturing312112 | 100–499 | ◐ LIKELY ACTIVE |
| OPOpus Packaging - Florence | Florence, SC | Paper Manufacturing322211 | 20–99 | ◐ LIKELY ACTIVE |
| PPPalmetto Prosthetics and Orthotics, INC. | Florence, SC | Miscellaneous Manufacturing339113 | — | ◐ LIKELY ACTIVE |