| CLContraband LLC | Rapid City, SD | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| CSCreative Surfaces of the Black Hills | Rapid City, SD | Furniture and Related Product Manufacturing337212 | 20–99 | ◐ LIKELY ACTIVE |
| DFDakota Fluid Power Rapid City | Rapid City, SD | Fabricated Metal Product Manufacturing332912 | 20–99 | ◐ LIKELY ACTIVE |
| DSDakota Sign CO | Rapid City, SD | Printing and Related Support Activities323111 | — | ◐ LIKELY ACTIVE |
| DDDohrman Design and Manufacturing LLC | Piedmont, SD | Fabricated Metal Product Manufacturing332323 | — | ◐ LIKELY ACTIVE |
| FWFeuillerat Welding, LLC | Rapid City, SD | Machinery Manufacturing333248 | — | ◐ LIKELY ACTIVE |
| FSFirehouse Smokejumper Station | Hill City, SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| FWFirehouse Wine Cellars | Rapid City, SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| FPForest Products Distributors, INC. | Rapid City, SD | Wood Product Manufacturing321113 | — | ◐ LIKELY ACTIVE |
| FTFull Throttle Sloon Shine, LLC | Vale, SD | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| HPHigh Plains Metalworks LLC | Sturgis, SD | Fabricated Metal Product Manufacturing332710 | — | ◐ LIKELY ACTIVE |
| HPHills Products Group, INC. | Rapid City, SD | Wood Product Manufacturing321114 | — | ◐ LIKELY ACTIVE |
| HIHorner Industries INC. | Rapid City, SD | Fabricated Metal Product Manufacturing332999 | — | ◐ LIKELY ACTIVE |
| ITImmutrix Therapeutics, INC. | Rapid City, SD | Miscellaneous Manufacturing339112 | — | ◐ LIKELY ACTIVE |
| JKJeremiah Klein and Lisa Klein | Hill City, SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| LELakota Enterprises INC | Rapid City, SD | Miscellaneous Manufacturing339940 | — | ◐ LIKELY ACTIVE |
| MAMatthew a Ramsey | Ellsworth Afb, SD | Transportation Equipment Manufacturing336411 | — | ◐ LIKELY ACTIVE |
| MCMRBC Cidery | Custer, SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| PLPete Lien & Sons Rapid City Central Mix | Rapid City, SD | Nonmetallic Mineral Product Manufacturing327320 | 20–99 | ◐ LIKELY ACTIVE |
| PDProSmiles Dental Studio | Rapid City, SD | Miscellaneous Manufacturing339116 | 20–99 | ◐ LIKELY ACTIVE |
| RCRapid City (1016) | Rapid City, SD | Nonmetallic Mineral Product Manufacturing327320 | 20–99 | ◐ LIKELY ACTIVE |
| RCRapid City, USA | Rapid City, SD | Computer and Electronic Product Manufacturing334511 | 20–99 | ◐ LIKELY ACTIVE |
| SCSimon - Custer Ready Mix | Custer, SD | Nonmetallic Mineral Product Manufacturing327320 | 1–19 | ◐ LIKELY ACTIVE |
| SRSimon - Rapid City Concrete Plant | Rapid City, SD | Nonmetallic Mineral Product Manufacturing327320 | 1–19 | ◐ LIKELY ACTIVE |
| SFStone Faces Winery | Hill City, SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| SSStonemeadow Springs Winery | Custer, SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| SMSturgis Meats LLC | Sturgis, SD | Food Manufacturing311611 | — | ◐ LIKELY ACTIVE |
| TTTemperature Technology, INC. | Rapid City, SD | Computer and Electronic Product Manufacturing334512 | — | ◐ LIKELY ACTIVE |
| TETorres Enterprises LLC | Rapid City, SD | Printing and Related Support Activities323113 | — | ◐ LIKELY ACTIVE |
| UWUplifted Winery | Rapid City, SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| WMWall Meats Processing | Wall, SD | Food Manufacturing311611 | — | ◐ LIKELY ACTIVE |
| WMWall Meats Rapid | Rapid City, SD | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| WWcm | Rapid City, SD | Fabricated Metal Product Manufacturing332321 | 20–99 | ◐ LIKELY ACTIVE |
| WIWild Idea Buffalo Suppliers | Hermosa, SD | Food Manufacturing311611 | — | ◐ LIKELY ACTIVE |
| WHWinery Hill City, LLC | Hill City, SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| WCWise Cat | Sturgis, SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| WPWL Plastics - Rapid City | Rapid City, SD | Plastics and Rubber Products Manufacturing326122 | 20–99 | ◐ LIKELY ACTIVE |
| ZIZendeavor Interplanetary, LLC | Owanka, SD | Transportation Equipment Manufacturing336414 | — | ◐ LIKELY ACTIVE |
| ZBZymurcracy Beer Company | Rapid City, SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| AHAiden Holdings LLC | Rapid City, SD | Miscellaneous Manufacturing339999 | — | ◇ UNVERIFIED |
| AEApex Electric & Sign LLC | Rapid City, SD | Miscellaneous Manufacturing339950 | — | ◇ UNVERIFIED |
| BIBabl Industries, LLC | Black Hawk, SD | Machinery Manufacturing333120 | — | ◇ UNVERIFIED |
| BHBlack Hills Railings LLC | Rapid City, SD | Fabricated Metal Product Manufacturing332323 | — | ◇ UNVERIFIED |
| BFBranson Family Holdings LLC | Rapid City, SD | Primary Metal Manufacturing331210 | — | ◇ UNVERIFIED |
| CBCohort Black Hills, LLC | Hill City, SD | Beverage and Tobacco Product Manufacturing312120 | — | ◇ UNVERIFIED |
| CNCupcakes N' Schmitt LLC | Rapid City, SD | Food Manufacturing311811 | — | ◇ UNVERIFIED |
| CECutting Edge Components, LLC | Black Hawk, SD | Transportation Equipment Manufacturing336991 | — | ◇ UNVERIFIED |
| DBDakota Biochar LLC | Rapid City, SD | Chemical Manufacturing325194 | — | ◇ UNVERIFIED |
| DBDakota Butcher - Rapid City, Inc. | Rapid City, SD | Food Manufacturing311615 | — | ◇ UNVERIFIED |
| FAFM Acquisition LLC | Rapid City, SD | Printing and Related Support Activities323111 | — | ◇ UNVERIFIED |