| SESpartan Erv | Brandon, SD | Transportation Equipment Manufacturing336211 | — | ◇ UNVERIFIED |
| SESpartan Erv | Brandon, SD | Machinery Manufacturing333924 | — | ◇ UNVERIFIED |
| SCSweetman Const. CO. - Corson Complex | Brandon, SD | Nonmetallic Mineral Product Manufacturing327320 | — | ◇ UNVERIFIED |
| SCSweetman Const. CO. - E. Rice St. Distribution Complex | Sioux Falls, SD | Nonmetallic Mineral Product Manufacturing327320 | — | ◇ UNVERIFIED |
| SCSweetman Const. CO. - W. Madison St. Complex | Sioux Falls, SD | Nonmetallic Mineral Product Manufacturing327320 | — | ◇ UNVERIFIED |
| TSTcc - Sioux Falls | Sioux Falls, SD | Nonmetallic Mineral Product Manufacturing327320 | — | ◇ UNVERIFIED |
| UCUnited Concrete | Harrisburg, SD | Nonmetallic Mineral Product Manufacturing327320 | — | ◇ UNVERIFIED |
| VIViaflex, INC. | Brandon, SD | Plastics and Rubber Products Manufacturing326113 | — | ◇ UNVERIFIED |
| WIWinter, INC. | Sioux Falls, SD | Nonmetallic Mineral Product Manufacturing327390 | — | ◇ UNVERIFIED |
| WEWoods Equipment CO | Sioux Falls, SD | Machinery Manufacturing333111 | — | ◇ UNVERIFIED |
| AMAbilene Machine, LLC Sioux Falls | Sioux Falls, SD | Machinery Manufacturing333111 | 1–19 | ◐ LIKELY ACTIVE |
| ARAce Ready Mix- Harrisburg | Harrisburg, SD | Nonmetallic Mineral Product Manufacturing327320 | 20–99 | ◐ LIKELY ACTIVE |
| AAAdvanced Ag Products | Canton, SD | Food Manufacturing311119 | 20–99 | ◐ LIKELY ACTIVE |
| AHAGI Hansen Hi Roller | Sioux Falls, SD | Machinery Manufacturing333922 | 100–499 | ◐ LIKELY ACTIVE |
| ANAgriCare Nutrition | Sioux Falls, SD | Food Manufacturing311119 | 20–99 | ◐ LIKELY ACTIVE |
| AFAmesburyTruth-Sioux Falls | Sioux Falls, SD | Fabricated Metal Product Manufacturing332321 | 100–499 | ◐ LIKELY ACTIVE |
| BSBCI - Sioux Falls Division | Sioux Falls, SD | Paper Manufacturing322211 | 20–99 | ◐ LIKELY ACTIVE |
| BGBerry Global LLC | Sioux Falls, SD | Plastics and Rubber Products Manufacturing326111 | 100–499 | ◐ LIKELY ACTIVE |
| BFBlackFork Farms | Sioux Falls, SD | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| B4Branch 418 | Sioux Falls, SD | Miscellaneous Manufacturing339115 | 1–19 | ◐ LIKELY ACTIVE |
| BABreadsmith-Duluth ave | Sioux Falls, SD | Food Manufacturing311811 | 1–19 | ◐ LIKELY ACTIVE |
| BEBreadsmith East | Sioux Falls, SD | Food Manufacturing311811 | 1–19 | ◐ LIKELY ACTIVE |
| BSBreadsmith South | Sioux Falls, SD | Food Manufacturing311811 | 1–19 | ◐ LIKELY ACTIVE |
| BWBreadsmith West | Sioux Falls, SD | Food Manufacturing311811 | 1–19 | ◐ LIKELY ACTIVE |
| BRBuffalo Ridge Concrete Inc. | Sioux Falls, SD | Nonmetallic Mineral Product Manufacturing327320 | 20–99 | ◐ LIKELY ACTIVE |
| BPBuilding Products Inc. of SD (Millwork) | Sioux Falls, SD | Wood Product Manufacturing321911 | 20–99 | ◐ LIKELY ACTIVE |
| CHCCL Healthcare | Sioux Falls, SD | Printing and Related Support Activities323111 | 20–99 | ◐ LIKELY ACTIVE |
| CLCCL Label SF1 | Sioux Falls, SD | Printing and Related Support Activities323111 | 100–499 | ◐ LIKELY ACTIVE |
| CPCorrugated Packaging Sioux Falls CT | Sioux Falls, SD | Paper Manufacturing322211 | 100–499 | ◐ LIKELY ACTIVE |
| CCorson | Corson, SD | Food Manufacturing311119 | 20–99 | ◐ LIKELY ACTIVE |
| C1Curt - 141 | Brandon, SD | Transportation Equipment Manufacturing336390 | 20–99 | ◐ LIKELY ACTIVE |
| CMCurt Manufacturing LLC | Brandon, SD | Transportation Equipment Manufacturing336390 | — | ◐ LIKELY ACTIVE |
| CMCut Meat Creek Custom | Chancellor, SD | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| DFDakota Falls | Brandon, SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| DFDakota Fluid Power OEM | Sioux Falls, SD | Fabricated Metal Product Manufacturing332912 | 20–99 | ◐ LIKELY ACTIVE |
| DFDakota Fluid Power SF | Sioux Falls, SD | Fabricated Metal Product Manufacturing332912 | 20–99 | ◐ LIKELY ACTIVE |
| DMDakotaland Manufacturing | Sioux Falls, SD | Fabricated Metal Product Manufacturing332216 | 100–499 | ◐ LIKELY ACTIVE |
| ESEast Side Jersey Dairy - Sioux Falls Operations | Sioux Falls, SD | Food Manufacturing311511 | 20–99 | ◐ LIKELY ACTIVE |
| FSFCP Sioux Falls | Sioux Falls, SD | Printing and Related Support Activities323111 | 20–99 | ◐ LIKELY ACTIVE |
| FEFermentation Experts USA LLC | Sioux Falls, SD | Food Manufacturing311119 | 20–99 | ◐ LIKELY ACTIVE |
| FDFernson Distilling Co. | Sioux Falls, SD | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| FDFernson Distilling Co. | Sioux Falls, SD | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| FMFirst Manufacturing, LLC - Humboldt | Humboldt, SD | Machinery Manufacturing333517 | 1–19 | ◐ LIKELY ACTIVE |
| FGFive Glass Winery & Vineyard | Sioux Falls, SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| GDG&H Distributing | Sioux Falls, SD | Plastics and Rubber Products Manufacturing326220 | 20–99 | ◐ LIKELY ACTIVE |
| GLGlacial Lakes Distillery and Brewhouse LLC | Sioux Falls, SD | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| GPGrand Prairie Foods, Inc. | Sioux Falls, SD | Food Manufacturing311999 | — | ◐ LIKELY ACTIVE |
| GPGrand Prairie Foods, Inc. | Sioux Falls, SD | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| HHHumble Hill Winery | Garretson, SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| KPKamps Pallets - Sioux Falls | Sioux Falls, SD | Wood Product Manufacturing321920 | 1–19 | ◐ LIKELY ACTIVE |