| RBRobert Bosch LLC | Charleston | SC | Transportation Equipment Manufacturing336310 | 500+ | ◐ LIKELY ACTIVE |
| BABaum America CORP | Charleston | WV | Fabricated Metal Product Manufacturing332996 | 20-99 | ◐ LIKELY ACTIVE |
| DCDow Chemical CO | Charleston | IL | Plastics and Rubber Products Manufacturing326140 | — | ◐ LIKELY ACTIVE |
| HSHoneywell Salisbury | Charleston | SC | Miscellaneous Manufacturing339113 | — | ◐ LIKELY ACTIVE |
| LCLanxess Corporation - Charleston, Sc Plant | Charleston | SC | Chemical Manufacturing325110 | — | ◐ LIKELY ACTIVE |
| UCUnion Carbide CORP Technology Park | Charleston | WV | Chemical Manufacturing325110 | — | ◐ LIKELY ACTIVE |
| VUVesuvius USA | Charleston | IL | Nonmetallic Mineral Product Manufacturing327120 | — | ◐ LIKELY ACTIVE |
| WPWacker Polysilicon North America | Charleston | TN | Chemical Manufacturing325132 | 500+ | ◐ LIKELY ACTIVE |
| MEMerit Energy Company, LLC - Tobey Compressor Station | Charleston | AR | Wood Product Manufacturing321114 | — | ◐ LIKELY ACTIVE |
| MMetalkraft | Charleston | PA | Fabricated Metal Product Manufacturing332117 | — | ◐ LIKELY ACTIVE |
Latin Collection, LLC | Charleston | SC | Apparel Manufacturing315120 | — | ◐ LIKELY ACTIVE |
Ripple Two LLC | Charleston | SC | Computer and Electronic Product Manufacturing334220 | — | ◐ LIKELY ACTIVE |
| ASAmerican Sail INC | Charleston | SC | Transportation Equipment Manufacturing336612 | — | ◐ LIKELY ACTIVE |
| CFCharleston Farrier | Charleston | IL | Nonmetallic Mineral Product Manufacturing327320 | 1-19 | ◐ LIKELY ACTIVE |
| CICharleston Industries INC | Charleston | MS | Miscellaneous Manufacturing339950 | — | ◐ LIKELY ACTIVE |
| CTChem Treat C/o Wacker Polysilicon | Charleston | TN | Chemical Manufacturing325998 | — | ◐ LIKELY ACTIVE |
| CPChevron Products Company | Charleston | SC | Petroleum and Coal Products Manufacturing324191 | — | ◐ LIKELY ACTIVE |
| EIEastern Illinois University | Charleston | IL | Miscellaneous Manufacturing339999 | — | ◐ LIKELY ACTIVE |
| HSHoneywell Salisbury-n Charleston Plant | Charleston | SC | Apparel Manufacturing315299 | — | ◐ LIKELY ACTIVE |
| ICIngevity Corporation Technical and Innovation Center | Charleston | SC | Chemical Manufacturing325191 | — | ◐ LIKELY ACTIVE |
| IHItw Hi-cone | Charleston | IL | Plastics and Rubber Products Manufacturing326199 | — | ◐ LIKELY ACTIVE |
| JCJj Collins Sons INC | Charleston | IL | Printing and Related Support Activities323111 | — | ◐ LIKELY ACTIVE |
| NANe-co Asphalt CO | Charleston | IL | Petroleum and Coal Products Manufacturing324121 | — | ◐ LIKELY ACTIVE |
| TUThe Urban Electric Company - Arc | Charleston | SC | Electrical Equipment, Appliance & Component Manufacturing335131 | — | ◐ LIKELY ACTIVE |
| VSVan Smith Concrete Company - Clements Ferry Plant | Charleston | SC | Nonmetallic Mineral Product Manufacturing327320 | — | ◐ LIKELY ACTIVE |
| BCBanks Construction Company - North Charleston | Charleston | SC | Petroleum and Coal Products Manufacturing324121 | — | ◐ LIKELY ACTIVE |
| CSConcrete Supply CO LLC - Cherry Hill | Charleston | SC | Nonmetallic Mineral Product Manufacturing327320 | — | ◐ LIKELY ACTIVE |
| CICorrell Incorporated | Charleston | AR | Furniture and Related Product Manufacturing337211 | — | ◐ LIKELY ACTIVE |
| CTCummins Turbo Technologies | Charleston | SC | Machinery Manufacturing333618 | — | ◐ LIKELY ACTIVE |
| HFHeber-binggeli Facility | Charleston | UT | Nonmetallic Mineral Product Manufacturing327320 | — | ◐ LIKELY ACTIVE |
| MDMoore Drums INC | Charleston | SC | Fabricated Metal Product Manufacturing332439 | — | ◐ LIKELY ACTIVE |
| SCSmith Concrete Company - Charleston Plant | Charleston | WV | Nonmetallic Mineral Product Manufacturing327320 | — | ◐ LIKELY ACTIVE |
| 6C625 Charleston SC | Charleston | SC | Food Manufacturing311811 | 20-99 | ◐ LIKELY ACTIVE |
| ACAm Conservation Group INC. | Charleston | SC | Electrical Equipment, Appliance & Component Manufacturing335131 | — | ◐ LIKELY ACTIVE |
| ATAmplifiedag Technologies LLC | Charleston | SC | Machinery Manufacturing333111 | — | ◐ LIKELY ACTIVE |
| BBBevhaus Brands USA | Charleston | SC | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| CDCannon Distillery | Charleston | SC | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| CFCarolina Flag & Banner INC | Charleston | SC | Miscellaneous Manufacturing339999 | — | ◐ LIKELY ACTIVE |
| CFCharleston Facility | Charleston | SC | Food Manufacturing311221 | 20-99 | ◐ LIKELY ACTIVE |
| COCharleston - Ox | Charleston | IL | Plastics and Rubber Products Manufacturing326150 | 20-99 | ◐ LIKELY ACTIVE |
| CSCharleston Shop | Charleston | SC | Computer and Electronic Product Manufacturing334516 | 1-19 | ◐ LIKELY ACTIVE |
| CHCoastal Hydraulics | Charleston | SC | Machinery Manufacturing333995 | 20-99 | ◐ LIKELY ACTIVE |
| DSDaniel S Sagle | Charleston | SC | Machinery Manufacturing333514 | — | ◐ LIKELY ACTIVE |
| DEDefined Empowerment INC | Charleston | SC | Machinery Manufacturing333992 | — | ◐ LIKELY ACTIVE |
| EBExecutive Beverage | Charleston | SC | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| HDHardscoop Distillery | Charleston | SC | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| HAHaselden Acquisition, LLC | Charleston | SC | Machinery Manufacturing333241 | 20-99 | ◐ LIKELY ACTIVE |
| HCHi-Cone Charleston | Charleston | IL | Plastics and Rubber Products Manufacturing326199 | 20-99 | ◐ LIKELY ACTIVE |
| HWHigh Wire Distilling Co. | Charleston | SC | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| ISIngevity SC, LLC - Charleston Chemical Plant | Charleston | SC | Chemical Manufacturing325194 | 100-499 | ◐ LIKELY ACTIVE |