| KEKansas Ethanol, LLC | Lyons | KS | Chemical Manufacturing325193 | 20-99 | ◐ LIKELY ACTIVE |
| CCCemex Construction Materials South LLC | Lyons | CO | Nonmetallic Mineral Product Manufacturing327310 | — | ◐ LIKELY ACTIVE |
| COChicken of the Sea Ga Canning | Lyons | GA | Food Manufacturing311710 | 100-499 | ◐ LIKELY ACTIVE |
| CMCompass Minerals America | Lyons | KS | Food Manufacturing311942 | — | ◐ LIKELY ACTIVE |
| EPEast Penn Mfg CO Inc/battery Assembly | Lyons | PA | Plastics and Rubber Products Manufacturing326199 | — | ◐ LIKELY ACTIVE |
| MAMidland Asphalt Materials - Lyons Terminal | Lyons | NY | Petroleum and Coal Products Manufacturing324110 | — | ◐ LIKELY ACTIVE |
| EPEast Penn Mfg CO Inc/smelter Plt | Lyons | PA | Primary Metal Manufacturing331492 | — | ◐ LIKELY ACTIVE |
| FLFreres Lumber CO. INC. | Lyons | OR | Wood Product Manufacturing321113 | — | ◐ LIKELY ACTIVE |
Jamestown Container Rochester Inc. HP Neun Division | Lyons | NY | Plastics and Rubber Products Manufacturing326140 | 1-19 | ◐ LIKELY ACTIVE |
| MAMid America Ready Mix - Lyons Plant | Lyons | KS | Nonmetallic Mineral Product Manufacturing327320 | — | ◐ LIKELY ACTIVE |
| FLFrank Lumber Company | Lyons | OR | Wood Product Manufacturing321113 | — | ◐ LIKELY ACTIVE |
| 8W8424 W. 47th Street | Lyons | IL | Food Manufacturing311615 | 1-19 | ◐ LIKELY ACTIVE |
| ATatlas tool | Lyons | IL | Fabricated Metal Product Manufacturing332119 | 20-99 | ◐ LIKELY ACTIVE |
| BWB W Supply Company | Lyons | OH | Primary Metal Manufacturing331511 | 20-99 | ◐ LIKELY ACTIVE |
| CWCiatano Winery | Lyons | CO | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| DDeloka | Lyons | NY | Fabricated Metal Product Manufacturing332812 | 1-19 | ◐ LIKELY ACTIVE |
| EJEast Jordan Plastics Lyons GA | Lyons | GA | Plastics and Rubber Products Manufacturing326199 | 20-99 | ◐ LIKELY ACTIVE |
| LMLyons Manufacturing Company, INC. | Lyons | KS | Transportation Equipment Manufacturing336413 | — | ◐ LIKELY ACTIVE |
| SHSpirit Hound Distillers | Lyons | CO | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| SSSunspot Solutions LLC | Lyons | IN | Fabricated Metal Product Manufacturing332710 | — | ◐ LIKELY ACTIVE |
| WEWesLor Enterprises, Inc. | Lyons | NY | Fabricated Metal Product Manufacturing332322 | 20-99 | ◐ LIKELY ACTIVE |
| ZMZen Machine & Scientific Instrument, LLC | Lyons | CO | Fabricated Metal Product Manufacturing332710 | — | ◐ LIKELY ACTIVE |