Boston Scientific CORP | Spencer | IN | Miscellaneous Manufacturing339112 | 500+ | ● ACTIVE |
| FCFlexcon Co, INC | Spencer | MA | Plastics and Rubber Products Manufacturing326112 | — | ● ACTIVE |
Blueshift Materials INC | Spencer | MA | Plastics and Rubber Products Manufacturing326150 | — | ● ACTIVE |
| TITecton Industries, INC. | Spencer | IA | Fabricated Metal Product Manufacturing332710 | — | ● ACTIVE |
The Raymond Hadley CORP | Spencer | NY | Food Manufacturing311824 | 20-99 | ● ACTIVE |
Cayuga Astronautics LLC | Spencer | NY | Transportation Equipment Manufacturing336419 | — | ● ACTIVE |
Mustang Survival Mfg, INC. | Spencer | WV | Apparel Manufacturing315250 | — | ● ACTIVE |
Prairie & Plot Specialty Equipment LLC | Spencer | IA | Machinery Manufacturing333111 | — | ● ACTIVE |
| VFVeridian Fire Protective Gear, LLC | Spencer | IA | Apparel Manufacturing315210 | — | ● ACTIVE |
| RIRamrod Industries LLC | Spencer | WI | Machinery Manufacturing333995 | 20-99 | ◐ LIKELY ACTIVE |
| DMDemco Manufacturing Company - Spencer | Spencer | IA | Machinery Manufacturing333111 | 20-99 | ◐ LIKELY ACTIVE |
| IHIndiana Hardwood Specialists INC | Spencer | IN | Wood Product Manufacturing321918 | 20-99 | ◐ LIKELY ACTIVE |
| ILIndiana Limestone Fabricators | Spencer | IN | Nonmetallic Mineral Product Manufacturing327991 | 20-99 | ◐ LIKELY ACTIVE |
| IPInnospec Performance Chemicals US CO | Spencer | NC | Chemical Manufacturing325613 | — | ◐ LIKELY ACTIVE |
| WAWorld Arts Incorporated | Spencer | IN | Printing and Related Support Activities323111 | 20-99 | ◐ LIKELY ACTIVE |
| CLCamcar LLC - Spencer Operations | Spencer | TN | Fabricated Metal Product Manufacturing332722 | — | ◐ LIKELY ACTIVE |
| ALArmacell LLC | Spencer | WV | Plastics and Rubber Products Manufacturing326299 | — | ◇ UNVERIFIED |
| LOLand Olakes Spencer | Spencer | WI | Food Manufacturing311513 | — | ◇ UNVERIFIED |
| CBColonial Brass Company | Spencer | MA | Miscellaneous Manufacturing339950 | — | ◐ LIKELY ACTIVE |
| AMAlta Mira CORP | Spencer | OH | Fabricated Metal Product Manufacturing332111 | — | ◐ LIKELY ACTIVE |
| ALArmacell LLC | Spencer | WV | Plastics and Rubber Products Manufacturing326150 | 20-99 | ◐ LIKELY ACTIVE |
| BSB&b Specialties INC | Spencer | WI | Food Manufacturing311119 | — | ◐ LIKELY ACTIVE |
| GMGeneral Machine Works CO INC | Spencer | IA | Fabricated Metal Product Manufacturing332710 | — | ◐ LIKELY ACTIVE |
| MWMercury Wire Products | Spencer | MA | Electrical Equipment, Appliance & Component Manufacturing335929 | 100-499 | ◐ LIKELY ACTIVE |
| SFSpencer Forge & Mfg. | Spencer | OH | Fabricated Metal Product Manufacturing332111 | 1-19 | ◐ LIKELY ACTIVE |
| SJSt Josephs Abbey | Spencer | MA | Food Manufacturing311421 | — | ◐ LIKELY ACTIVE |
| DNDienes & Neuenkamp INC | Spencer | MA | Fabricated Metal Product Manufacturing332215 | — | ◐ LIKELY ACTIVE |
| BCBond Construction Corporation | Spencer | MA | Petroleum and Coal Products Manufacturing324121 | — | ◇ UNVERIFIED |
| FCFlexcon Company INC Plant 1 | Spencer | MA | Textile Mills313320 | — | ◇ UNVERIFIED |
| GCGoodrich Corporation, Spencer | Spencer | WV | Textile Mills313320 | — | ◇ UNVERIFIED |
| GCGoodrich Corporation Spencer Operations | Spencer | WV | Plastics and Rubber Products Manufacturing326299 | — | ◇ UNVERIFIED |
| ILIndiana Limestone Supply Incorporated | Spencer | IN | Nonmetallic Mineral Product Manufacturing327991 | — | ◇ UNVERIFIED |
| KCKellwood CO Spencer Plant | Spencer | WV | Apparel Manufacturing315191 | — | ◇ UNVERIFIED |
| LOLand O Lakes Purina Feed Plant | Spencer | WI | Food Manufacturing311110 | — | ◇ UNVERIFIED |
| RCRustgo CO | Spencer | NE | Fabricated Metal Product Manufacturing332813 | — | ◇ UNVERIFIED |
| SFSpencer Feed & Supply, LLC | Spencer | OH | Food Manufacturing311119 | — | ◇ UNVERIFIED |
| SVSpencer Veneer, Llc, Spencer | Spencer | WV | Wood Product Manufacturing321211 | — | ◇ UNVERIFIED |
| SPStello Products INC | Spencer | IN | Miscellaneous Manufacturing339950 | — | ◇ UNVERIFIED |
| AWAbram Winery | Spencer | IN | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| CFCentury Farms Distillery | Spencer | IA | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| CRChestnut Ridge Winery, LLC | Spencer | WV | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| GNGOMACO North | Spencer | IA | Machinery Manufacturing333120 | 1-19 | ◐ LIKELY ACTIVE |
| HHHenry Holsters LLC | Spencer | IN | Fabricated Metal Product Manufacturing332710 | — | ◐ LIKELY ACTIVE |
| LOLand O Lakes Spencer, WI | Spencer | WI | Food Manufacturing311513 | 100-499 | ◐ LIKELY ACTIVE |
| OVOwen Valley Winery | Spencer | IN | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| QRQuality Refrigerated Services, Inc. | Spencer | IA | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| RVRoane Vineyards | Spencer | WV | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| SCSEK Corporation / Ayotte | Spencer | MA | Nonmetallic Mineral Product Manufacturing327390 | 1-19 | ◐ LIKELY ACTIVE |
| SSymrise | Spencer | IA | Food Manufacturing311111 | 1-19 | ◐ LIKELY ACTIVE |
| TSThe Sweeter Side of the Feud, INC. | Spencer | WV | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |