| PBPoet Biorefining Big Stone | Big Stone City | SD | Chemical Manufacturing325193 | 20-99 | ◐ LIKELY ACTIVE |
| BFBenchmark Foam, INC. | Watertown | SD | Chemical Manufacturing325211 | 20-99 | ◐ LIKELY ACTIVE |
| OTOtter Tail Power Company | Big Stone City | SD | Chemical Manufacturing325193 | — | ◐ LIKELY ACTIVE |
| PEPrairie Ethanol, LLC | Mitchell | SD | Chemical Manufacturing325110 | — | ◐ LIKELY ACTIVE |
| TOTech Ord, a Division of Amtec Corporation | Clear Lake | SD | Chemical Manufacturing325920 | 100-499 | ◐ LIKELY ACTIVE |
| VRValero Renewable Fuels Company | Aurora | SD | Chemical Manufacturing325110 | — | ◐ LIKELY ACTIVE |
| HCHub City Energy LLC | Aberdeen | SD | Chemical Manufacturing325193 | — | ◐ LIKELY ACTIVE |
| HEHuron Energy Llc, Dba Glacial Lakes Energy LLC | Huron | SD | Chemical Manufacturing325193 | — | ◐ LIKELY ACTIVE |
| ISIdic Specialty Drilling Chemicals LLC | Belle Fourche | SD | Chemical Manufacturing325998 | — | ◐ LIKELY ACTIVE |
| SESiouxland Energy Cooperative | Hudson | SD | Chemical Manufacturing325998 | — | ◐ LIKELY ACTIVE |
| ACAgland Coop | Parkston | SD | Chemical Manufacturing325311 | — | ◐ LIKELY ACTIVE |
| DPDak Pak LLC | Woonsocket | SD | Chemical Manufacturing325412 | 20-99 | ◐ LIKELY ACTIVE |
| DRD & R Propane, INC. | Eagle Butte | SD | Chemical Manufacturing325120 | — | ◐ LIKELY ACTIVE |
| EPETRIA Products USA INC. | Mitchell | SD | Chemical Manufacturing325992 | 20-99 | ◐ LIKELY ACTIVE |
| FSFinishWorks (Tea, SD) | Tea | SD | Chemical Manufacturing325510 | 1-19 | ◐ LIKELY ACTIVE |
| FCFull Circle Ag | Britton | SD | Chemical Manufacturing325314 | — | ◐ LIKELY ACTIVE |
| MMedgene | Brookings | SD | Chemical Manufacturing325414 | 100-499 | ◐ LIKELY ACTIVE |
| RERing-neck Energy & Feed, LLC | Onida | SD | Chemical Manufacturing325193 | — | ◐ LIKELY ACTIVE |
| SLSenproco, LLC | Sioux Falls | SD | Chemical Manufacturing325611 | 20-99 | ◐ LIKELY ACTIVE |
| VRValero Renewable Fuels Company, LLC dba Valero Aurora Plant | Aurora | SD | Chemical Manufacturing325193 | 20-99 | ◐ LIKELY ACTIVE |