| CSCreative Surfaces INC | Sioux Falls | SD | Furniture and Related Product Manufacturing337212 | 100-499 | ◐ LIKELY ACTIVE |
| DIDaktronics Incorporated | Brookings | SD | Miscellaneous Manufacturing339950 | — | ◐ LIKELY ACTIVE |
| MMMajestic Medical LLC | Harrisburg | SD | Miscellaneous Manufacturing339113 | — | ◐ LIKELY ACTIVE |
| UIUltiMed Inc. | De Smet | SD | Miscellaneous Manufacturing339112 | 20-99 | ◐ LIKELY ACTIVE |
| PIPersona INC. - Watertown | Watertown | SD | Miscellaneous Manufacturing339950 | — | ◐ LIKELY ACTIVE |
| B4Branch 418 | Sioux Falls | SD | Miscellaneous Manufacturing339115 | 1-19 | ◐ LIKELY ACTIVE |
| BPBrookings-sd-falcon Plastics | Brookings | SD | Miscellaneous Manufacturing339113 | 1-19 | ◐ LIKELY ACTIVE |
| BWBrookings - Warehouse 1 | Brookings | SD | Miscellaneous Manufacturing339999 | 1-19 | ◐ LIKELY ACTIVE |
| BWBrookings - Warehouse 2 | Brookings | SD | Miscellaneous Manufacturing339999 | 1-19 | ◐ LIKELY ACTIVE |
| BWBrookings - Warehouse 3 | Brookings | SD | Miscellaneous Manufacturing339999 | 1-19 | ◐ LIKELY ACTIVE |
| ITImmutrix Therapeutics, INC. | Rapid City | SD | Miscellaneous Manufacturing339112 | — | ◐ LIKELY ACTIVE |
| LELakota Enterprises INC | Rapid City | SD | Miscellaneous Manufacturing339940 | — | ◐ LIKELY ACTIVE |
| NLNevr Looz LLC | Sioux Falls | SD | Miscellaneous Manufacturing339920 | — | ◐ LIKELY ACTIVE |
| PDProSmiles Dental Studio | Rapid City | SD | Miscellaneous Manufacturing339116 | 20-99 | ◐ LIKELY ACTIVE |
| PDProSmiles Dental Studio Sioux Falls | Sioux Falls | SD | Miscellaneous Manufacturing339116 | 1-19 | ◐ LIKELY ACTIVE |
| PRProsperous Robotics Group, INC. | Sioux Falls | SD | Miscellaneous Manufacturing339113 | — | ◐ LIKELY ACTIVE |
| RPRainbow Play Systems, Inc. | Brookings | SD | Miscellaneous Manufacturing339920 | 20-99 | ◐ LIKELY ACTIVE |
| RDRegional Dental Lab, LLC | Sioux Falls | SD | Miscellaneous Manufacturing339116 | — | ◐ LIKELY ACTIVE |
| SDSd02-dakt-south Dakota Sioux Falls | Sioux Falls | SD | Miscellaneous Manufacturing339950 | 100-499 | ◐ LIKELY ACTIVE |
| SDSouth Dakota | Brandon | SD | Miscellaneous Manufacturing339930 | 1-19 | ◐ LIKELY ACTIVE |
| WPWells Plumbing LLC | Belle Fourche | SD | Miscellaneous Manufacturing339999 | — | ◐ LIKELY ACTIVE |