| CFCal-Maine Foods-Newberry, SC Retail Feed Mill | Newberry | SC | Food Manufacturing311119 | 1-19 | ◐ LIKELY ACTIVE |
| CKCamden - KPR U.S. LLC | Camden | SC | Textile Mills313210 | 20-99 | ◐ LIKELY ACTIVE |
| CFCandy Friday Farms, LLC | Blythewood | SC | Chemical Manufacturing325320 | — | ◐ LIKELY ACTIVE |
| CDCannon Distillery | Charleston | SC | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| CECapecraft Enterprises LLC | Mount Pleasant | SC | Transportation Equipment Manufacturing336611 | — | ◐ LIKELY ACTIVE |
| CBCarolina Bauernhaus Ales | Anderson | SC | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| CBCarolina Brew Supply | Rock Hill | SC | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| CCCarolina Classic Winery | Columbia | SC | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| CCCarolina Custom Laserworks LLC | Spartanburg | SC | Printing and Related Support Activities323120 | — | ◐ LIKELY ACTIVE |
| CECarolina Egg Products | Newberry | SC | Food Manufacturing311999 | 20-99 | ◐ LIKELY ACTIVE |
| CFCarolina Flag & Banner INC | Charleston | SC | Miscellaneous Manufacturing339999 | — | ◐ LIKELY ACTIVE |
| CFCarolina Fresh Foods | Florence | SC | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| CICarolina Integrated Solutions, Inc. | Spartanburg | SC | Fabricated Metal Product Manufacturing332313 | 20-99 | ◐ LIKELY ACTIVE |
| CMCarolina Moon Distillery | Edgefield | SC | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| CSCarolina Surveying Equipment Sales LLC | Loris | SC | Computer and Electronic Product Manufacturing334220 | — | ◐ LIKELY ACTIVE |
| CVCarolina Vineyards | North Myrtle Beach | SC | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| CICarson Industries, INC. | Hilton Head Island | SC | Machinery Manufacturing333310 | — | ◐ LIKELY ACTIVE |
| CCCarter Component Plant 546 | Johnsonville | SC | Wood Product Manufacturing321214 | 20-99 | ◐ LIKELY ACTIVE |
| CFCarter Family Wines | Greenville | SC | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| CWCash Winery and Vineyard | Cheraw | SC | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| CPCat's Paw Winery | Rock Hill | SC | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| COCbc of Charleston INC | North Charleston | SC | Fabricated Metal Product Manufacturing332311 | — | ◐ LIKELY ACTIVE |
| CMCBS Marketing Solutions, Inc | Greer | SC | Printing and Related Support Activities323111 | 20-99 | ◐ LIKELY ACTIVE |
| CCCDI Charlotte | Rock Hill | SC | Fabricated Metal Product Manufacturing332322 | 100-499 | ◐ LIKELY ACTIVE |
| CICesco, INC. | North Charleston | SC | Machinery Manufacturing333517 | — | ◐ LIKELY ACTIVE |
| CGCF Gray Court | Gray Court | SC | Food Manufacturing311991 | 100-499 | ◐ LIKELY ACTIVE |
| CWChampion Window of Columbia | Columbia | SC | Plastics and Rubber Products Manufacturing326121 | 20-99 | ◐ LIKELY ACTIVE |
| CWChampion Window of Greenville | Greenville | SC | Plastics and Rubber Products Manufacturing326121 | 1-19 | ◐ LIKELY ACTIVE |
| CDCharleston Distilling CO Ii, LLC | Johns Island | SC | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| CFCharleston Facility | Charleston | SC | Food Manufacturing311221 | 20-99 | ◐ LIKELY ACTIVE |
| CICharleston Industrial and Marine Repair LLC | North Charleston | SC | Transportation Equipment Manufacturing336611 | — | ◐ LIKELY ACTIVE |
| CSCharleston SC IW Plant | North Charleston | SC | Chemical Manufacturing325910 | 20-99 | ◐ LIKELY ACTIVE |
| CSCharleston Shop | Charleston | SC | Computer and Electronic Product Manufacturing334516 | 1-19 | ◐ LIKELY ACTIVE |
| CIChart, Inc. Southeast Repair Facility | Richburg | SC | Fabricated Metal Product Manufacturing332420 | 1-19 | ◐ LIKELY ACTIVE |
| CBChattooga Belle Farm Distillery, LLC | Long Creek | SC | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| CCheraw | Cheraw | SC | Textile Mills313210 | 100-499 | ◐ LIKELY ACTIVE |
| CUChevron USA INC | North Charleston | SC | Petroleum and Coal Products Manufacturing324191 | — | ◐ LIKELY ACTIVE |
| CBChiron Bio, LLC | Irmo | SC | Chemical Manufacturing325412 | — | ◐ LIKELY ACTIVE |
| CNChomarat North America - Alliance Site | Williamston | SC | Textile Mills313230 | 20-99 | ◐ LIKELY ACTIVE |
| CNChomarat North America - Commerce Blvd Site | Anderson | SC | Textile Mills313230 | 1-19 | ◐ LIKELY ACTIVE |
| CBChromaScape Bushy Park Manufacturing Facility | Goose Creek | SC | Chemical Manufacturing325130 | 20-99 | ◐ LIKELY ACTIVE |
| CSCitadel Shipworks, LLC | Mount Pleasant | SC | Transportation Equipment Manufacturing336611 | — | ◐ LIKELY ACTIVE |
| CSCity Scape Winery | Greenville | SC | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| CSCity Scape Winery, LLC | Pelzer | SC | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| CCCKS Charleston | Hanahan | SC | Plastics and Rubber Products Manufacturing326160 | 20-99 | ◐ LIKELY ACTIVE |
| CFClarios - Florence SC DC | Florence | SC | Electrical Equipment, Appliance & Component Manufacturing335911 | 100-499 | ◐ LIKELY ACTIVE |
| CGCL&D Graphics The Rock | Rock Hill | SC | Printing and Related Support Activities323111 | 20-99 | ◐ LIKELY ACTIVE |
| CRCMC Rebar Columbia | Columbia | SC | Fabricated Metal Product Manufacturing332312 | 20-99 | ◐ LIKELY ACTIVE |
| CSCMC Southern Post South Carolina | Cayce | SC | Fabricated Metal Product Manufacturing332323 | 20-99 | ◐ LIKELY ACTIVE |
| CMCMMC Machine, LLC | North Charleston | SC | Fabricated Metal Product Manufacturing332710 | 20-99 | ◐ LIKELY ACTIVE |