| TCTwin City Fan LTD | Elkton | SD | Machinery Manufacturing333412 | — | ◐ LIKELY ACTIVE |
| UIUltiMed Inc. | De Smet | SD | Miscellaneous Manufacturing339112 | 20-99 | ◐ LIKELY ACTIVE |
| VIVermeer INC. | Freeman | SD | Textile Product Mills314999 | — | ◐ LIKELY ACTIVE |
| WTWilson Trailer Yankton | Yankton | SD | Machinery Manufacturing333111 | 100-499 | ◐ LIKELY ACTIVE |
| AHAmpi - Hoven | Hoven | SD | Food Manufacturing311513 | — | ◐ LIKELY ACTIVE |
| AIAstec Industries | Yankton | SD | Machinery Manufacturing333120 | — | ◐ LIKELY ACTIVE |
| CCCustom Coils INC | Alcester | SD | Electrical Equipment, Appliance & Component Manufacturing335311 | — | ◐ LIKELY ACTIVE |
| CFCustom Fabricators INC. | Watertown | SD | Fabricated Metal Product Manufacturing332999 | — | ◐ LIKELY ACTIVE |
Dakota Bodies, LLC | Watertown | SD | Transportation Equipment Manufacturing336211 | — | ◐ LIKELY ACTIVE |
| DPDakota Pork Industries | Mitchell | SD | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| EDEast Dakotas Renewable Energy, LLC | Centerville | SD | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| GPGraphic Packaging International LLC | Mitchell | SD | Paper Manufacturing322212 | — | ◐ LIKELY ACTIVE |
| HPHills Products Group - Whitewood Treating Plant | Whitewood | SD | Wood Product Manufacturing321114 | — | ◐ LIKELY ACTIVE |
| IMInfinity Machine LLC | Rapid City | SD | Fabricated Metal Product Manufacturing332710 | — | ◐ LIKELY ACTIVE |
| JEJerry's Electric, INC | Colman | SD | Computer and Electronic Product Manufacturing334416 | — | ◐ LIKELY ACTIVE |
| LEL.g. Everist, INC. - East Sioux Quarry | Sioux Falls | SD | Petroleum and Coal Products Manufacturing324121 | — | ◐ LIKELY ACTIVE |
| LELumber Exchange, LLC C/o Lloyd Companies | Sioux Falls | SD | Computer and Electronic Product Manufacturing334512 | — | ◐ LIKELY ACTIVE |
| MWMaguire Water | Sioux Falls | SD | Fabricated Metal Product Manufacturing332420 | — | ◐ LIKELY ACTIVE |
| MMMasaba Mining Equipment | Vermillion | SD | Machinery Manufacturing333131 | — | ◐ LIKELY ACTIVE |
| PIPersona INC. - Watertown | Watertown | SD | Miscellaneous Manufacturing339950 | — | ◐ LIKELY ACTIVE |
| PCPresidio Components, INC | Sioux Falls | SD | Computer and Electronic Product Manufacturing334416 | — | ◐ LIKELY ACTIVE |
| SESiouxland Energy Cooperative | Hudson | SD | Chemical Manufacturing325998 | — | ◐ LIKELY ACTIVE |
| SMSioux Marble, INC. | Brandon | SD | Plastics and Rubber Products Manufacturing326191 | — | ◐ LIKELY ACTIVE |
| TSTerex South Dakota - Main Plant | Watertown | SD | Machinery Manufacturing333120 | — | ◐ LIKELY ACTIVE |
| TITrail-eze INC. | Platte | SD | Transportation Equipment Manufacturing336212 | — | ◐ LIKELY ACTIVE |
| TCTwin City Fan Companies | Mitchell | SD | Machinery Manufacturing333412 | — | ◐ LIKELY ACTIVE |
| 2C21st Century Mfg. | Lake Preston | SD | Machinery Manufacturing333515 | 20-99 | ◐ LIKELY ACTIVE |
| DP"4083 - Dakota Panel Pick and Assembly" | Rapid City | SD | Wood Product Manufacturing321212 | 20-99 | ◐ LIKELY ACTIVE |
| AAberdeen | Aberdeen | SD | Textile Mills313230 | 500+ | ◐ LIKELY ACTIVE |
| AMAberdeen Machine Tool Inc. | Aberdeen | SD | Machinery Manufacturing333517 | 20-99 | ◐ LIKELY ACTIVE |
| AMAbilene Machine, LLC Sioux Falls | Sioux Falls | SD | Machinery Manufacturing333111 | 1-19 | ◐ LIKELY ACTIVE |
| AAAdvanced Ag Products | Canton | SD | Food Manufacturing311119 | 20-99 | ◐ LIKELY ACTIVE |
| APAFCO Performance Group dba Legend Suspensions | Sturgis | SD | Transportation Equipment Manufacturing336211 | 20-99 | ◐ LIKELY ACTIVE |
| ACAgland Coop | Parkston | SD | Chemical Manufacturing325311 | — | ◐ LIKELY ACTIVE |
| AAAGP Aberdeen Soy | Aberdeen | SD | Food Manufacturing311224 | 20-99 | ◐ LIKELY ACTIVE |
| ANAgriCare Nutrition | Sioux Falls | SD | Food Manufacturing311119 | 20-99 | ◐ LIKELY ACTIVE |
| ALAgropur Lake Norden | Lake Norden | SD | Food Manufacturing311513 | 100-499 | ◐ LIKELY ACTIVE |
| AFAlbany Farms | Belle Fourche | SD | Food Manufacturing311999 | 20-99 | ◐ LIKELY ACTIVE |
| ADAmerican Defense Builders Trust | Hot Springs | SD | Transportation Equipment Manufacturing336411 | — | ◐ LIKELY ACTIVE |
| AFAmesburyTruth-Sioux Falls | Sioux Falls | SD | Fabricated Metal Product Manufacturing332321 | 100-499 | ◐ LIKELY ACTIVE |
| AFArlington Feed Mill | Arlington | SD | Food Manufacturing311119 | 1-19 | ◐ LIKELY ACTIVE |
| BDBadlands Distillery LLC | Kadoka | SD | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| BRBad River Jerky | Chamberlain | SD | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| BTBaker Timber Products Inc. | Rapid City | SD | Wood Product Manufacturing321113 | 20-99 | ◐ LIKELY ACTIVE |
| BEBanner Engineering- Aberdeen, SD | Aberdeen | SD | Electrical Equipment, Appliance & Component Manufacturing335314 | 20-99 | ◐ LIKELY ACTIVE |
| BVBaumberger Vineyard and Winery | Dell Rapids | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| BSBCI - Sioux Falls Division | Sioux Falls | SD | Paper Manufacturing322211 | 20-99 | ◐ LIKELY ACTIVE |
| BJBelle Joli Winery | Deadwood | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| BGBerry Global LLC | Sioux Falls | SD | Plastics and Rubber Products Manufacturing326111 | 100-499 | ◐ LIKELY ACTIVE |
| BBBickering Brothers | Pierre | SD | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |