| WSWestern's Smokehouse | Greentop, MO | Food Manufacturing311612 | 100–499 | ● ACTIVE |
 Wireco Worldgroup INC. | Kirksville, MO | Fabricated Metal Product Manufacturing332618 | — | ● ACTIVE |
| HHHartzell Hardwoods Kirksville | Kirksville, MO | Wood Product Manufacturing321114 | 20–99 | ◐ LIKELY ACTIVE |
| OOOsage Orange Vineyard and Winery | Greencastle, MO | Food Manufacturing311611 | — | ◐ LIKELY ACTIVE |
| KFKraft Foods Global | Kirksville, MO | Food Manufacturing311612 | — | ◇ UNVERIFIED |
| BLBroadleaf Lumber Company | Downing, MO | Wood Product Manufacturing321114 | — | ◇ UNVERIFIED |
| CECommercial Envelope Manufacturing CO. | Kirksville, MO | Printing and Related Support Activities323116 | — | ◇ UNVERIFIED |
| GMGatehouse Media Dba Kirksville Daily Express | Kirksville, MO | Printing and Related Support Activities323111 | — | ◇ UNVERIFIED |
| HIHollister Inc-div of Schneider INC | Kirksville, MO | Plastics and Rubber Products Manufacturing326111 | — | ◇ UNVERIFIED |
| HTHy Test Incorporated | Kirksville, MO | Leather and Allied Product Manufacturing316213 | — | ◇ UNVERIFIED |
| KRKirksville Ready Mix North | Kirksville, MO | Nonmetallic Mineral Product Manufacturing327320 | — | ◇ UNVERIFIED |
| OOrtech | Kirksville, MO | Fabricated Metal Product Manufacturing332618 | — | ◇ UNVERIFIED |
| WCWarren County Concrete - Kirksville North | Kirksville, MO | Nonmetallic Mineral Product Manufacturing327320 | — | ◇ UNVERIFIED |
| WLW L Miller Company-kirksville Plant | Kirksville, MO | Petroleum and Coal Products Manufacturing324121 | — | ◇ UNVERIFIED |
 Cenveo Worldwide Limited Kirksville | Kirksville, MO | Paper Manufacturing322230 | 20–99 | ◐ LIKELY ACTIVE |
| JVJacob's Vineyard | Kirksville, MO | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| KHKraft Heinz Food Company | Kirksville, MO | Food Manufacturing311612 | 500+ | ◐ LIKELY ACTIVE |
| KHKraft Heinz Foods Company | Kirksville, MO | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| RPRuth Premium Meat, LLC | Queen City, MO | Food Manufacturing311611 | — | ◐ LIKELY ACTIVE |
| WireCo WorldGroup Kirksville | Kirksville, MO | Fabricated Metal Product Manufacturing332618 | 20–99 | ◐ LIKELY ACTIVE |
| HFHarris Fabrication and Welding | Lancaster, MO | Machinery Manufacturing333992 | — | ◇ UNVERIFIED |
| HHHartzell Hardwoods | Kirksville, MO | Wood Product Manufacturing321113 | — | ◇ UNVERIFIED |
| WCWarren County Concrete - Kirksville South | Kirksville, MO | Nonmetallic Mineral Product Manufacturing327320 | — | ◇ UNVERIFIED |
