Custom Electronics, INC. | Oneonta, NY | Computer and Electronic Product Manufacturing334414 | 20–99 | ● ACTIVE |
| ACApple Converting INC | Oneonta, NY | Printing and Related Support Activities323111 | 20–99 | ● ACTIVE |
Mold-a-matic CORP | Oneonta, NY | Plastics and Rubber Products Manufacturing326199 | — | ● ACTIVE |
Astrocom Electronics INC | Oneonta, NY | Computer and Electronic Product Manufacturing334290 | — | ● ACTIVE |
Comminnovations INC | Oneonta, NY | Computer and Electronic Product Manufacturing334220 | — | ● ACTIVE |
| CICorning Inc - Oneonta | Oneonta, NY | Plastics and Rubber Products Manufacturing326160 | 100–499 | ● ACTIVE |
Hanger Prosthetics & Orthotics East, INC. | Oneonta, NY | Miscellaneous Manufacturing339113 | — | ● ACTIVE |
Systematic Power Manufacturing LLC | Oneonta, NY | Computer and Electronic Product Manufacturing334416 | — | ● ACTIVE |
Thistle Hill Weavers | Cherry Valley, NY | Textile Mills313210 | — | ● ACTIVE |
| NSN S Brandon Packing Inc. | Otego, NY | Food Manufacturing311611 | — | ◐ LIKELY ACTIVE |
| OROtsego Ready Mix | Oneonta, NY | Nonmetallic Mineral Product Manufacturing327320 | 20–99 | ◐ LIKELY ACTIVE |
| CACeperley Ave Site | Oneonta, NY | Petroleum and Coal Products Manufacturing324121 | — | ◐ LIKELY ACTIVE |
| PAPm Adirondack LLC | Fly Creek, NY | Leather and Allied Product Manufacturing316990 | — | ◐ LIKELY ACTIVE |
| HWH W Naylor CO | Morris, NY | Chemical Manufacturing325412 | — | ◇ UNVERIFIED |
| SOSuit-kote Oneonta | Oneonta, NY | Petroleum and Coal Products Manufacturing324121 | — | ◇ UNVERIFIED |
| 1D1639 Distillery LLC | Otego, NY | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| BPBear Pond, INC. | Oneonta, NY | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| BRBurt Rigid Box | Oneonta, NY | Paper Manufacturing322219 | 20–99 | ◐ LIKELY ACTIVE |
| CDCooperstown Distillery | Cooperstown, NY | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| CDCooperstown Distilling Company LLC | Oneonta, NY | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| FCFly Creek Cider Mill & Orchard, INC. | Fly Creek, NY | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| HFHoneyPot Farms Meadery Eatery | Burlington Flats, NY | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| LFLutz Feed Co. | Oneonta, NY | Food Manufacturing311119 | 20–99 | ◐ LIKELY ACTIVE |
| MMasseria | New Berlin, NY | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| MTMosconi, Toni Marie | Oneonta, NY | Apparel Manufacturing315990 | — | ◐ LIKELY ACTIVE |
| PSPail Shop Vineyards LLC | Fly Creek, NY | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| RMR.J. Millworkers | Oneonta, NY | Wood Product Manufacturing321918 | 20–99 | ◐ LIKELY ACTIVE |
| RRRustic Ridge Winery | Burlington Flats, NY | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| TSThe Sparrowhawk | Schenevus, NY | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| TMTrinity Meat Company LLC | Hartwick, NY | Food Manufacturing311611 | — | ◐ LIKELY ACTIVE |
| ABAdvanced Biotech | Oneonta, NY | Chemical Manufacturing325199 | — | ◇ UNVERIFIED |
| BABarrister and Mann LLC | Hartwick, NY | Chemical Manufacturing325620 | — | ◇ UNVERIFIED |
| BBBrooks' Bottling Co., LLC | Oneonta, NY | Food Manufacturing311941 | — | ◇ UNVERIFIED |
| BBButternuts Beer and Ale, LLC | Garrattsville, NY | Beverage and Tobacco Product Manufacturing312120 | — | ◇ UNVERIFIED |
| BBButternuts Beer and Ale, LLC | Garrattsville, NY | Beverage and Tobacco Product Manufacturing312120 | — | ◇ UNVERIFIED |
| COCo-optics of America Vision Group, INC. | Oneonta, NY | Miscellaneous Manufacturing339115 | — | ◇ UNVERIFIED |
| DMDuvel Moortgat USA LTD | Cooperstown, NY | Beverage and Tobacco Product Manufacturing312120 | — | ◇ UNVERIFIED |
| LTLeatherstocking Timber Products, INC. | Oneonta, NY | Wood Product Manufacturing321113 | — | ◇ UNVERIFIED |
Morton Buildings | Cooperstown, NY | Fabricated Metal Product Manufacturing332311 | — | ◇ UNVERIFIED |
| SBSauvage Beverages | Oneonta, NY | Beverage and Tobacco Product Manufacturing312111 | — | ◇ UNVERIFIED |
| TAThe Ames Companies of New York | Unadilla, NY | Wood Product Manufacturing321999 | — | ◇ UNVERIFIED |
| TMToonie Moonie Organics, Ltd. | Oneonta, NY | Food Manufacturing311340 | — | ◇ UNVERIFIED |
| TMToonie Moonie Organics, Ltd. | Fly Creek, NY | Food Manufacturing311340 | — | ◇ UNVERIFIED |
| TMToonie Moonie Organics, Ltd. | Oneonta, NY | Food Manufacturing311340 | — | ◇ UNVERIFIED |