| NINascote Industries INC | Nashville | Machinery Manufacturing | 333249 | 500+ | ● ACTIVE |
| ANAntolin Nashville | Nashville | Transportation Equipment Manufacturing | 336390 | — | ◐ LIKELY ACTIVE |
| PSPrairie State Generating Station | Marissa | Plastics and Rubber Products Manufacturing | 326199 | — | ◇ UNVERIFIED |
 Purina Animal Nutrition LLC | Nashville | Food Manufacturing | 311119 | — | ◇ UNVERIFIED |
| BRBeelman Ready Mix | Nashville | Nonmetallic Mineral Product Manufacturing | 327320 | — | ◇ UNVERIFIED |
| PCPeabody Coal CO | Marissa | Miscellaneous Manufacturing | 339999 | — | ◇ UNVERIFIED |
| PPPullman Power LLC | Marissa | Plastics and Rubber Products Manufacturing | 326199 | — | ◇ UNVERIFIED |
| QCQuad County Ready Mix | Nashville | Nonmetallic Mineral Product Manufacturing | 327320 | — | ◇ UNVERIFIED |
| QRQuad-county Ready Mix | Okawville | Nonmetallic Mineral Product Manufacturing | 327320 | — | ◇ UNVERIFIED |
| USUnited Science Industries INC | Okawville | Miscellaneous Manufacturing | 339999 | — | ◇ UNVERIFIED |
 Wastequip Manufacturing CO Dba Rayfo | Marissa | Fabricated Metal Product Manufacturing | 332999 | — | ◇ UNVERIFIED |
| ASAntolin Southern Illinois, LLC (dba Antolin Nashville) | Nashville | Transportation Equipment Manufacturing | 336360 | 100–499 | ◐ LIKELY ACTIVE |
| BHBlacksheep Holdings, LLC | Okawville | Food Manufacturing | 311612 | — | ◐ LIKELY ACTIVE |
| FMFred's Meat and Processing | Ashley | Food Manufacturing | 311611 | — | ◐ LIKELY ACTIVE |
| NINascote Industries - Mockingbird Road | Nashville | Transportation Equipment Manufacturing | 336390 | 100–499 | ◐ LIKELY ACTIVE |
| NMNascote - Mockingbird Road 2 | Nashville | Transportation Equipment Manufacturing | 336390 | 100–499 | ◐ LIKELY ACTIVE |
| BJBarb Johnson | Ashley | Miscellaneous Manufacturing | 339999 | — | ◇ UNVERIFIED |
| DBDavid Bening | Okawville | Miscellaneous Manufacturing | 339999 | — | ◇ UNVERIFIED |
| EIEcolab INC | Richview | Miscellaneous Manufacturing | 339999 | — | ◇ UNVERIFIED |
| GFGateway Fs INC | Nashville | Chemical Manufacturing | 325314 | — | ◇ UNVERIFIED |
| GFGateway Fs INC | Nashville | Chemical Manufacturing | 325314 | — | ◇ UNVERIFIED |
| GBGenes Body Shop | Nashville | Miscellaneous Manufacturing | 339999 | — | ◇ UNVERIFIED |
| JMJim Marvel | Wamac | Miscellaneous Manufacturing | 339999 | — | ◇ UNVERIFIED |
| JDJohn Dorrierty | Ashley | Miscellaneous Manufacturing | 339999 | — | ◇ UNVERIFIED |
| LRLulla Rensing | Okawville | Miscellaneous Manufacturing | 339999 | — | ◇ UNVERIFIED |
| MEMagna Exterior and Interiors Usa, INC. Dba Innertech - Nashville | Nashville | Transportation Equipment Manufacturing | 336399 | — | ◇ UNVERIFIED |
| NINascote Industries INC Ilvs Operations | Nashville | Miscellaneous Manufacturing | 339999 | — | ◇ UNVERIFIED |
| NKNashville Knapp Mart | Nashville | Miscellaneous Manufacturing | 339999 | — | ◇ UNVERIFIED |
| RSRemington Seeds LLC | Nashville | Miscellaneous Manufacturing | 339999 | — | ◇ UNVERIFIED |
| RRRoad Ranger 157 | Okawville | Miscellaneous Manufacturing | 339999 | — | ◇ UNVERIFIED |
| SCSisco Corporation | Nashville | Paper Manufacturing | 322211 | — | ◇ UNVERIFIED |
| TDTom Dillinger | Centralia | Miscellaneous Manufacturing | 339999 | — | ◇ UNVERIFIED |
| VOVillage of Okawville | Okawville | Miscellaneous Manufacturing | 339999 | — | ◇ UNVERIFIED |
| WAWarren Auto Body INC | Nashville | Miscellaneous Manufacturing | 339999 | — | ◇ UNVERIFIED |
| WSWiechert Seed CO INC | Nashville | Miscellaneous Manufacturing | 339999 | — | ◇ UNVERIFIED |
| WNWilliams Nick | Nashville | Miscellaneous Manufacturing | 339999 | — | ◇ UNVERIFIED |
| YTYoung Terry | Irvington | Miscellaneous Manufacturing | 339999 | — | ◇ UNVERIFIED |
