| SGSrg Global Coatings, INC. | Portageville | Plastics and Rubber Products Manufacturing | 326121 | 100–499 | ● ACTIVE |
| BSBrown Sand & Gravel Dba Heartland Asphalt Materials | New Madrid | Petroleum and Coal Products Manufacturing | 324121 | — | ◐ LIKELY ACTIVE |
| RFRiceland Foods INC - New Madrid | Marston | Food Manufacturing | 311212 | 20–99 | ◐ LIKELY ACTIVE |
| CPCrop Production Services 4014 | Portageville | Chemical Manufacturing | 325314 | — | ◐ LIKELY ACTIVE |
| M7Magnitude 7 Metals LLC | Marston | Primary Metal Manufacturing | 331312 | — | ◐ LIKELY ACTIVE |
| SRSemo Ready Mix | Sikeston | Nonmetallic Mineral Product Manufacturing | 327320 | — | ◐ LIKELY ACTIVE |
| AWAlan Wire CO INC | Sikeston | Primary Metal Manufacturing | 331222 | — | ◐ LIKELY ACTIVE |
| CICargill INC | New Madrid | Food Manufacturing | 311119 | — | ◐ LIKELY ACTIVE |
| RARiverbend Ag LLC | New Madrid | Chemical Manufacturing | 325314 | — | ◐ LIKELY ACTIVE |
| AAAgrium Advanced Technologies | Marston | Chemical Manufacturing | 325311 | — | ◇ UNVERIFIED |
| AIAgxplore International LLC | Parma | Chemical Manufacturing | 325314 | — | ◇ UNVERIFIED |
| CCCarlisle Construction Materials, LLC | Sikeston | Plastics and Rubber Products Manufacturing | 326150 | — | ◇ UNVERIFIED |
| CPCrop Production Serivces 4013 | Sikeston | Chemical Manufacturing | 325314 | — | ◇ UNVERIFIED |
| DADelta Asphalt INC - New Madrid Plant | New Madrid | Petroleum and Coal Products Manufacturing | 324121 | — | ◇ UNVERIFIED |
| GLGlycetech LLC | Lilbourn | Food Manufacturing | 311222 | — | ◇ UNVERIFIED |
| HHHimmelberger - Harrison | Morehouse | Furniture and Related Product Manufacturing | 337122 | — | ◇ UNVERIFIED |
| NBNova Brik Midamerica Llc-sikeston | Sikeston | Nonmetallic Mineral Product Manufacturing | 327320 | — | ◇ UNVERIFIED |
| SCSoutheast Coop Service CO | Morehouse | Chemical Manufacturing | 325314 | — | ◇ UNVERIFIED |
| SASpecialloy Acquisition Company | New Madrid | Wood Product Manufacturing | 321114 | — | ◇ UNVERIFIED |
| SFS-r Finishing-div Siegel-robert INC | Portageville | Plastics and Rubber Products Manufacturing | 326121 | — | ◇ UNVERIFIED |
| UIUnilever Ice Cream Sikeston South | Sikeston | Food Manufacturing | 311520 | — | ◇ UNVERIFIED |
| RBRefresco Beverages | Sikeston | Beverage and Tobacco Product Manufacturing | 312111 | 100–499 | ◐ LIKELY ACTIVE |
| DCDewitt Company | Sikeston | Textile Mills | 313312 | — | ◇ UNVERIFIED |
| KMKoch Materials-koch Materials | New Madrid | Petroleum and Coal Products Manufacturing | 324121 | — | ◇ UNVERIFIED |
| RFRiceland Foods Inc-marston | Marston | Food Manufacturing | 311212 | — | ◇ UNVERIFIED |
| SRSemo Ready Mix - Marston Site | Marston | Nonmetallic Mineral Product Manufacturing | 327320 | — | ◇ UNVERIFIED |
| SRSemo Ready Mix - Sikeston West | Sikeston | Nonmetallic Mineral Product Manufacturing | 327320 | — | ◇ UNVERIFIED |