 General Mills Hannibal | Hannibal | Food Manufacturing | 311230 | 500+ | ● ACTIVE |
| JPJones Poultry Hannibal | Hannibal | Food Manufacturing | 311615 | 20–99 | ● ACTIVE |
| CCContinental Cement Company, LLC | Hannibal | Nonmetallic Mineral Product Manufacturing | 327310 | — | ◐ LIKELY ACTIVE |
| AHAspeq Holdings | Monroe City | Machinery Manufacturing | 333415 | — | ◇ UNVERIFIED |
| EIEnduro Industries LLC | Hannibal | Fabricated Metal Product Manufacturing | 332813 | — | ◇ UNVERIFIED |
| EFEnnis Flint | Hannibal | Chemical Manufacturing | 325510 | — | ◇ UNVERIFIED |
| POPillsbury (subsidiary of General Mills) | Hannibal | Food Manufacturing | 311412 | — | ◐ LIKELY ACTIVE |
| BRBuckhorn Rubber Products INC | Hannibal | Plastics and Rubber Products Manufacturing | 326220 | — | ◇ UNVERIFIED |
| CICosmoflex INC | Hannibal | Plastics and Rubber Products Manufacturing | 326220 | — | ◇ UNVERIFIED |
| EPEss - Plant #4 | Monroe City | Petroleum and Coal Products Manufacturing | 324121 | — | ◇ UNVERIFIED |
| HCHannibal Cable Operatins-dura South | Hannibal | Transportation Equipment Manufacturing | 336340 | — | ◇ UNVERIFIED |
| PMPerry Machine & Die INC. | Perry | Textile Mills | 313320 | — | ◇ UNVERIFIED |
| SDSweetwater Distillery | Monroe City | Beverage and Tobacco Product Manufacturing | 312140 | — | ◐ LIKELY ACTIVE |
| EPEnnis Paint INC Saverton | Hannibal | Chemical Manufacturing | 325510 | — | ◇ UNVERIFIED |
| LTLakeside Technology Solutions LLC | Monroe City | Fabricated Metal Product Manufacturing | 332999 | — | ◇ UNVERIFIED |
| VTVeyance Technologies | Hannibal | Plastics and Rubber Products Manufacturing | 326220 | — | ◇ UNVERIFIED |
| WWatlow | Hannibal | Machinery Manufacturing | 333994 | — | ◇ UNVERIFIED |
| ZUZhongding USA Hannibal INC. | Hannibal | Plastics and Rubber Products Manufacturing | 326220 | — | ◇ UNVERIFIED |
