| LMLeviton Manufacturing CO | West Jefferson | Chemical Manufacturing | 325991 | 20–99 | ◐ LIKELY ACTIVE |
| GAGe Aerospace | West Jefferson | Transportation Equipment Manufacturing | 336412 | — | ◇ UNVERIFIED |
| CCCobble Creek Lumber Hice Avenue | West Jefferson | Wood Product Manufacturing | 321912 | — | ◐ LIKELY ACTIVE |
| JRJames R Vannoy & Sons Construction | Jefferson | Petroleum and Coal Products Manufacturing | 324121 | — | ◐ LIKELY ACTIVE |
| UCUnited Chemi-con, INC. | Lansing | Computer and Electronic Product Manufacturing | 334414 | 100–499 | ◐ LIKELY ACTIVE |
| LMLeviton Manufacturing Co., INC. | West Jefferson | Chemical Manufacturing | 325991 | — | ◐ LIKELY ACTIVE |
| AEAmerican Emergency Vehicles | Jefferson | Transportation Equipment Manufacturing | 336211 | — | ◇ UNVERIFIED |
| CCChandler Concrete Co., INC. - West Jefferson | West Jefferson | Nonmetallic Mineral Product Manufacturing | 327320 | — | ◇ UNVERIFIED |
| HGHalcore Group, INC. Dba American Emergency Vehicles | Jefferson | Transportation Equipment Manufacturing | 336211 | — | ◇ UNVERIFIED |
| PMPaddy Mountain Lumber CO Incorporated | Jefferson | Wood Product Manufacturing | 321113 | — | ◇ UNVERIFIED |
| PMPaddy Mountain Lumber, INC. - M & N Woo | W Jefferson | Wood Product Manufacturing | 321114 | — | ◇ UNVERIFIED |
| TGThe Gates Corporation | Jefferson | Plastics and Rubber Products Manufacturing | 326220 | — | ◇ UNVERIFIED |
| AVA.B. Vannoy Hams | West Jefferson | Food Manufacturing | 311612 | — | ◐ LIKELY ACTIVE |
| FMFishel's Moravian Style Chicken Pies | Crumpler | Food Manufacturing | 311615 | — | ◐ LIKELY ACTIVE |
| IMIntegrated Manufacturing West Jefferson NC | West Jefferson | Machinery Manufacturing | 333517 | 100–499 | ◐ LIKELY ACTIVE |
| MCMolley Chomper | Lansing | Beverage and Tobacco Product Manufacturing | 312130 | — | ◐ LIKELY ACTIVE |
| OBOld Barn Winery | West Jefferson | Beverage and Tobacco Product Manufacturing | 312130 | — | ◐ LIKELY ACTIVE |
| GMGlobal Manufacturing Services, INC. | West Jefferson | Computer and Electronic Product Manufacturing | 334412 | — | ◇ UNVERIFIED |
| HGHalcore Group, INC | Jefferson | Transportation Equipment Manufacturing | 336211 | — | ◇ UNVERIFIED |
| HGHalcore Group INC. Dba American Emergency Vehicles | Jefferson | Transportation Equipment Manufacturing | 336111 | — | ◇ UNVERIFIED |
| MMMaymead Materials, Inc.- Jefferson Plant | Crumpler | Petroleum and Coal Products Manufacturing | 324121 | — | ◇ UNVERIFIED |
| MMM - M Stone Sculpting | Todd | Nonmetallic Mineral Product Manufacturing | 327991 | — | ◇ UNVERIFIED |
| OIOssiriand, Inc. | Creston | Wood Product Manufacturing | 321113 | — | ◇ UNVERIFIED |
| PMPaddy Mountain Lumber, INC. - M & N Wood Products | West Jefferson | Wood Product Manufacturing | 321114 | — | ◇ UNVERIFIED |