| BFBellisio Foods | Jackson | Food Manufacturing | 311412 | 500+ | ● ACTIVE |
General Mills INC | Wellston | Food Manufacturing | 311211 | 500+ | ● ACTIVE |
| OIOsco Industries INC - Jackson Div | Jackson | Primary Metal Manufacturing | 331511 | 100–499 | ● ACTIVE |
| AOAluchem of Jackson INC | Jackson | Nonmetallic Mineral Product Manufacturing | 327992 | 20–99 | ● ACTIVE |
| SBSpeyside Bourbon Cooperage, INC. | Jackson | Wood Product Manufacturing | 321920 | 100–499 | ◐ LIKELY ACTIVE |
| LTLewis Turkey Farm, INC. | Oak Hill | Food Manufacturing | 311615 | — | ◐ LIKELY ACTIVE |
| MMMckee Materials - Plant 2 | Wellston | Petroleum and Coal Products Manufacturing | 324121 | — | ◐ LIKELY ACTIVE |
| SHSuperior Hardwoods of Ohio, Inc. : Wellston Division | Wellston | Wood Product Manufacturing | 321113 | 20–99 | ◐ LIKELY ACTIVE |
| WAWellston Aerosol Mfg CO INC | Wellston | Chemical Manufacturing | 325998 | — | ◐ LIKELY ACTIVE |
| CHCedar Heights Clay CO (0640010010) | Oak Hill | Nonmetallic Mineral Product Manufacturing | 327120 | — | ◐ LIKELY ACTIVE |
| AGAp Green Refractories | Oak Hill | Nonmetallic Mineral Product Manufacturing | 327124 | — | ◇ UNVERIFIED |
| DIDgm INC. | Jackson | Nonmetallic Mineral Product Manufacturing | 327320 | — | ◇ UNVERIFIED |
| FMFrick-gallagher Manufacturing Site | Wellston | Furniture and Related Product Manufacturing | 337000 | — | ◇ UNVERIFIED |
| GLGreene Lyon Metals LLC | Jackson | Primary Metal Manufacturing | 331492 | — | ◇ UNVERIFIED |
| KSKonya Sands LLC | Jackson | Nonmetallic Mineral Product Manufacturing | 327999 | — | ◇ UNVERIFIED |
| MAMeridian Automotive | Jackson | Plastics and Rubber Products Manufacturing | 326199 | — | ◇ UNVERIFIED |
| NSNock & Son CO | Oak Hill | Nonmetallic Mineral Product Manufacturing | 327120 | — | ◇ UNVERIFIED |
| OPOhio Precious Metals LLC | Jackson | Primary Metal Manufacturing | 331000 | — | ◇ UNVERIFIED |
| SBSpeyside Bourbon Cooperage, INC. (0640010020) | Jackson | Wood Product Manufacturing | 321920 | — | ◇ UNVERIFIED |
| JJackson | Jackson | Primary Metal Manufacturing | 331511 | 100–499 | ◐ LIKELY ACTIVE |
| MMMontgomery Machine & Fabrication Inc | Jackson | Fabricated Metal Product Manufacturing | 332710 | 20–99 | ◐ LIKELY ACTIVE |
| SSSixth Sense Brewing | Jackson | Beverage and Tobacco Product Manufacturing | 312130 | — | ◐ LIKELY ACTIVE |
| WBWiseman Brothers Fabricating & Steel Ltd. | Beaver | Fabricated Metal Product Manufacturing | 332710 | 20–99 | ◐ LIKELY ACTIVE |
| BCBrown-forman Cooperage | Wellston | Wood Product Manufacturing | 321113 | — | ◇ UNVERIFIED |
| CPColeman Packaging Corporation | Jackson | Paper Manufacturing | 322211 | — | ◇ UNVERIFIED |
| ERElemetal Refining LLC | Jackson | Primary Metal Manufacturing | 331492 | — | ◇ UNVERIFIED |
| HIHarbison-walker International | Oak Hill | Nonmetallic Mineral Product Manufacturing | 327125 | — | ◇ UNVERIFIED |