| STSumiriko Tennessee, INC. - Tazewell | Tazewell | Plastics and Rubber Products Manufacturing | 326291 | 500+ | ● ACTIVE |
| HIHomesteader INC | New Tazewell | Transportation Equipment Manufacturing | 336212 | 1–19 | ● ACTIVE |
| RSRoyal Sterilization Sys | New Tazewell | Computer and Electronic Product Manufacturing | 334510 | 20–99 | ◐ LIKELY ACTIVE |
| GIGiles Industries | New Tazewell | Wood Product Manufacturing | 321991 | — | ◇ UNVERIFIED |
Deroyal Industries, INC. | New Tazewell | Miscellaneous Manufacturing | 339113 | — | ◐ LIKELY ACTIVE |
| RGRogers Group, INC - Tazwell Asphalt | Tazewell | Petroleum and Coal Products Manufacturing | 324121 | — | ◐ LIKELY ACTIVE |
| BBushline | Tazewell | Furniture and Related Product Manufacturing | 337121 | — | ◐ LIKELY ACTIVE |
| RMReady Mix USA - New Tazewell | New Tazewell | Nonmetallic Mineral Product Manufacturing | 327320 | — | ◐ LIKELY ACTIVE |
| BFB & F Hot Mix Asphalt, INC. | Tazewell | Petroleum and Coal Products Manufacturing | 324121 | — | ◇ UNVERIFIED |
| BFBrooks Furniture Manufacturing INC | Tazewell | Furniture and Related Product Manufacturing | 337121 | — | ◇ UNVERIFIED |
| BFBrooks Furniture Manufacturing INC | Tazewell | Furniture and Related Product Manufacturing | 337121 | — | ◇ UNVERIFIED |
| EIEngland INC | New Tazewell | Furniture and Related Product Manufacturing | 337121 | — | ◇ UNVERIFIED |
| EIEngland, INC. | New Tazewell | Furniture and Related Product Manufacturing | 337121 | — | ◇ UNVERIFIED |
| EPEngland Plant / Lay - Z- Boy Logistics | New Tazewell | Furniture and Related Product Manufacturing | 337121 | — | ◇ UNVERIFIED |
| FLFt. Loudon Forest Products | Tazewell | Wood Product Manufacturing | 321920 | — | ◇ UNVERIFIED |
| 9C960 - Classic Panel | New Tazewell | Wood Product Manufacturing | 321991 | 20–99 | ◐ LIKELY ACTIVE |
| BDBlack Dog Distilling | Tazewell | Beverage and Tobacco Product Manufacturing | 312140 | — | ◐ LIKELY ACTIVE |
| BWBrooks Winery | Tazewell | Beverage and Tobacco Product Manufacturing | 312130 | — | ◐ LIKELY ACTIVE |
| CDCynthia Daniels | Harrogate | Wood Product Manufacturing | 321113 | — | ◐ LIKELY ACTIVE |
| DPDeRoyal Processing Center | New Tazewell | Miscellaneous Manufacturing | 339113 | 20–99 | ◐ LIKELY ACTIVE |
| DTDeRoyal Technologies | New Tazewell | Miscellaneous Manufacturing | 339113 | 20–99 | ◐ LIKELY ACTIVE |
| DHDown Home Processing, Inc. | Tazwell | Food Manufacturing | 311611 | — | ◐ LIKELY ACTIVE |
| JIJanco Inc. | New Tazewell | Transportation Equipment Manufacturing | 336212 | 100–499 | ◐ LIKELY ACTIVE |
| ASA Services Group Oldco LLC | New Tazewell | Furniture and Related Product Manufacturing | 337121 | — | ◇ UNVERIFIED |
| CICarapace INC | New Tazewell | Miscellaneous Manufacturing | 339113 | — | ◇ UNVERIFIED |
| EIEngland INC | New Tazewell | Furniture and Related Product Manufacturing | 337121 | — | ◇ UNVERIFIED |
| RDRepublic Diesel INC | Harrogate | Fabricated Metal Product Manufacturing | 332710 | — | ◇ UNVERIFIED |