| CICrafco, INC. - Halls | Halls | Petroleum and Coal Products Manufacturing | 324121 | 20–99 | ◐ LIKELY ACTIVE |
| AGAmerican Greeting Company | Ripley | Printing and Related Support Activities | 323110 | — | ◐ LIKELY ACTIVE |
| MWMarvin Windows of Tennessee, INC. | Ripley | Wood Product Manufacturing | 321911 | — | ◐ LIKELY ACTIVE |
| SRSrggi - Ripley | Ripley | Plastics and Rubber Products Manufacturing | 326199 | — | ◐ LIKELY ACTIVE |
| 5C51 Concrete Ripley Plant | Ripley | Nonmetallic Mineral Product Manufacturing | 327320 | — | ◇ UNVERIFIED |
| AOA. O. Smith Electrical Products CO. | Ripley | Electrical Equipment, Appliance & Component Manufacturing | 335312 | — | ◇ UNVERIFIED |
| PIPac-tec INC Ray-o-lite Div | Ripley | Plastics and Rubber Products Manufacturing | 326199 | — | ◇ UNVERIFIED |
| SRSiegel Robert Automotive Ripley South | Ripley | Fabricated Metal Product Manufacturing | 332813 | — | ◇ UNVERIFIED |
| TMTupperware Manufacturing | Halls | Plastics and Rubber Products Manufacturing | 326199 | — | ◇ UNVERIFIED |
| MWMarvin Windows and Doors - Ripley | Ripley | Wood Product Manufacturing | 321911 | 500+ | ◐ LIKELY ACTIVE |
| ARAllied Reprocessing LLC | Ripley | Chemical Manufacturing | 325991 | — | ◇ UNVERIFIED |
| FCFederal-mogul Corporation | Ripley | Transportation Equipment Manufacturing | 336399 | — | ◇ UNVERIFIED |
| JHJames Harper Dba the Pallet Shed | Henning | Wood Product Manufacturing | 321920 | — | ◇ UNVERIFIED |
| PPPierce Packaging Company | Ripley | Machinery Manufacturing | 333993 | — | ◇ UNVERIFIED |
| SISiegel-robert, INC | Ripley | Transportation Equipment Manufacturing | 336399 | — | ◇ UNVERIFIED |
| SISiegel-robert INC Dba Srg Global | Ripley | Transportation Equipment Manufacturing | 336399 | — | ◇ UNVERIFIED |
| WTWest Tennessee Pallet & Crate LLC | Halls | Wood Product Manufacturing | 321920 | — | ◇ UNVERIFIED |