| OVOld Virginia Hand Hewn Log Homes INC | Pennington Gap | Wood Product Manufacturing | 321999 | — | ◐ LIKELY ACTIVE |
| ACAmerican Concrete & Block Corporation | Pennington Gap | Nonmetallic Mineral Product Manufacturing | 327320 | — | ◐ LIKELY ACTIVE |
| JSJessee Stone Company | Pennington Gap | Petroleum and Coal Products Manufacturing | 324121 | — | ◐ LIKELY ACTIVE |
| EGElmo Greer & Sons Incorporated | Pennington Gap | Petroleum and Coal Products Manufacturing | 324121 | — | ◇ UNVERIFIED |
| LFLee Farmers Cooperative Incorporated | Jonesville | Food Manufacturing | 311119 | — | ◇ UNVERIFIED |
| NRNew River Hardwoods - Cumberland Gap Sawmill | Ewing | Wood Product Manufacturing | 321113 | — | ◇ UNVERIFIED |
| SBSynergy Biofuels LLC -2 | Pennington Gap | Chemical Manufacturing | 325110 | — | ◇ UNVERIFIED |
| DLDouble L Meat Processing | Jonesville | Food Manufacturing | 311611 | — | ◐ LIKELY ACTIVE |
| LBLawson Building Supply, INC | Rose Hill | Machinery Manufacturing | 333111 | — | ◐ LIKELY ACTIVE |
| WRWhite Rock Truss and Components LLC | Rose Hill | Wood Product Manufacturing | 321999 | — | ◇ UNVERIFIED |