| KCKollmorgen CORP | Radford | Electrical Equipment, Appliance & Component Manufacturing | 335312 | 100–499 | ● ACTIVE |
 Thermasteel INC | Radford | Plastics and Rubber Products Manufacturing | 326199 | — | ● ACTIVE |
 Acme Panel CO | Radford | Wood Product Manufacturing | 321992 | — | ● ACTIVE |
 Excel Prosthetics & Orthotics, INC. | Radford | Miscellaneous Manufacturing | 339113 | — | ● ACTIVE |
 Oransi LLC | Fairlawn | Machinery Manufacturing | 333413 | — | ● ACTIVE |
| KCKollmorgen Corporation | Radford | Electrical Equipment, Appliance & Component Manufacturing | 335312 | — | ◐ LIKELY ACTIVE |
| NRNew River Energetics - Radford Army Ammunition Plant | Radford | Chemical Manufacturing | 325920 | — | ◐ LIKELY ACTIVE |
| TITechlab, INC. | Radford | Chemical Manufacturing | 325413 | — | ◐ LIKELY ACTIVE |
| HFHuntington Foam LLC | Radford | Plastics and Rubber Products Manufacturing | 326122 | — | ◐ LIKELY ACTIVE |
| GTGoodyear Tire and Rubber Company | Radford | Plastics and Rubber Products Manufacturing | 326211 | — | ◇ UNVERIFIED |
| ICIntermet Corporation Radford | Radford | Primary Metal Manufacturing | 331511 | — | ◇ UNVERIFIED |
| MIMoog INC | Radford | Fabricated Metal Product Manufacturing | 332813 | — | ◇ UNVERIFIED |
| NRNew River Recycling | Radford | Wood Product Manufacturing | 321999 | — | ◇ UNVERIFIED |
| NINrb Industries INC Radford Plant | Radford | Textile Mills | 313210 | — | ◇ UNVERIFIED |
| PBPyrotechnique By Grucci, INC. | Radford | Chemical Manufacturing | 325998 | — | ◇ UNVERIFIED |
| RTRadford Trading, LLC | Radford | Primary Metal Manufacturing | 331511 | — | ◇ UNVERIFIED |
| ARAlleguard - Radford | Radford | Plastics and Rubber Products Manufacturing | 326140 | 20–99 | ◐ LIKELY ACTIVE |
| KIKollmorgen Industrial Drives (LC) KL1002 | Radford | Electrical Equipment, Appliance & Component Manufacturing | 335312 | 100–499 | ◐ LIKELY ACTIVE |
| RCRiver City Distillery | Radford | Beverage and Tobacco Product Manufacturing | 312140 | — | ◐ LIKELY ACTIVE |
| AMAspen Motion Technologies | Radford | Electrical Equipment, Appliance & Component Manufacturing | 335312 | — | ◇ UNVERIFIED |
| DEDjr Enterprises | Radford | Printing and Related Support Activities | 323113 | — | ◇ UNVERIFIED |
| MCMid Continent Nail CORP | Radford | Fabricated Metal Product Manufacturing | 332618 | — | ◇ UNVERIFIED |
| NINorman's INC | Radford | Furniture and Related Product Manufacturing | 337110 | — | ◇ UNVERIFIED |
| RARadford Army Ammunition Plant (bldgs 3741 & 3700) | Radford | Fabricated Metal Product Manufacturing | 332992 | — | ◇ UNVERIFIED |
| RCRadva Corporation - Radford | Radford | Plastics and Rubber Products Manufacturing | 326140 | — | ◇ UNVERIFIED |
