Mustang Survival Mfg, INC. | Spencer | Apparel Manufacturing | 315250 | — | ● ACTIVE |
| ALArmacell LLC | Spencer | Plastics and Rubber Products Manufacturing | 326299 | — | ◇ UNVERIFIED |
| ALArmacell LLC | Spencer | Plastics and Rubber Products Manufacturing | 326150 | 20–99 | ◐ LIKELY ACTIVE |
| GCGoodrich Corporation, Spencer | Spencer | Textile Mills | 313320 | — | ◇ UNVERIFIED |
| GCGoodrich Corporation Spencer Operations | Spencer | Plastics and Rubber Products Manufacturing | 326299 | — | ◇ UNVERIFIED |
| KCKellwood CO Spencer Plant | Spencer | Apparel Manufacturing | 315191 | — | ◇ UNVERIFIED |
| SVSpencer Veneer, Llc, Spencer | Spencer | Wood Product Manufacturing | 321211 | — | ◇ UNVERIFIED |
| SCStella-jones Corporation | Reedy | Wood Product Manufacturing | 321114 | — | ◇ UNVERIFIED |
| CRChestnut Ridge Winery, LLC | Spencer | Beverage and Tobacco Product Manufacturing | 312130 | — | ◐ LIKELY ACTIVE |
| RVRoane Vineyards | Spencer | Beverage and Tobacco Product Manufacturing | 312130 | — | ◐ LIKELY ACTIVE |
| TSThe Sweeter Side of the Feud, INC. | Spencer | Beverage and Tobacco Product Manufacturing | 312130 | — | ◐ LIKELY ACTIVE |
| VJVu Ja De Vineyards | Spencer | Beverage and Tobacco Product Manufacturing | 312130 | — | ◐ LIKELY ACTIVE |
| BSBosco Supply & Machine LLC | Spencer | Fabricated Metal Product Manufacturing | 332710 | — | ◇ UNVERIFIED |
| BCBurke-parsons-bowlby CORP | Spencer | Wood Product Manufacturing | 321114 | — | ◇ UNVERIFIED |
| CHCasto & Harris, INC. | Spencer | Printing and Related Support Activities | 323120 | — | ◇ UNVERIFIED |
| DHD & H Distributing Company | Walton | Transportation Equipment Manufacturing | 336212 | — | ◇ UNVERIFIED |